Opened 8 years ago

Closed 8 years ago

#156 closed enhancement (fixed)

IR - Index of Reactivity

Reported by: Gunther Schadow Owned by: Gunther Schadow
Priority: critical Milestone: Version 2.0
Component: Keywords:
Cc:

Description (last modified by Gunther Schadow)

IR (Index of Reactivity) : The unit IR has been defined to measure the allergenicity of an allergen extract. The allergen extract contains 100 IR/ml when, on a skin prick-test using a Stallerpoint®, it induces a wheal diameter of 7 mm in 30 patients sensitized to this allergen, (geometric mean). The cutaneous reactivity of these patients is simultaneously demonstrated by a positive skin prick-test to either 9 % codeine phosphate or 10 mg/ml histamine. The IR unit of Stallergenes is not comparable to the units used by other allergen manufacturers.

Reference:

http://www.stallergenes.com/fileadmin/images/corporate/gallery/Documents_pdf/RCP_Oralair.pdf Proposal for the code: [IR]

Change History (5)

comment:1 Changed 8 years ago by Gunther Schadow

Description: modified (diff)

comment:2 Changed 8 years ago by Gunther Schadow

Milestone: Version 2.0
Owner: set to Gunther Schadow
Priority: minorcritical
Status: newassigned
Type: questionenhancement

There is some urgency to get that in since FDA needs to register a product using that unit.

comment:3 Changed 8 years ago by Gunther Schadow

<u:unit id="600709" Code="[IR]" CODE="[IR]" isMetric="no" isArbitrary="yes"><name>index of reactivity</name><printSymbol>IR</printSymbol><property>amount of an allergen callibrated through in-vivo testing using the Stallergenes&reg; method.</property><value Unit="1" UNIT="1" value="1">1</value></u:unit>
<u:unit id="600710" Code="[BAU]" CODE="[BAU]" isMetric="no" isArbitrary="yes"><name>bioequivalent allergen unit</name><printSymbol>BAU</printSymbol><property>amount of an allergen callibrated through in-vivo testing based on the ID50EAL method of (intradermal dilution for 50mm sum of erythema diameters</property><value Unit="1" UNIT="1" value="1">1</value></u:unit>
<u:unit id="600711" Code="[AU]" CODE="[AU]" isMetric="no" isArbitrary="yes"><name>allergen unit</name><printSymbol>AU</printSymbol><property>procedure defined amount of an allergen using some reference standard</property><value Unit="1" UNIT="1" value="1">1</value></u:unit>
      <p>
The unit &ldquo;IR&rdquo; has been defined to measure the
allergenicity of an allergen extract. The allergen extract contains
100 IR/ml when, on a skin prick-test using a Stallerpoint&reg;, it induces
a wheal diameter of 7 mm in 30 patients sensitized to this allergen,
(geometric mean).  The cutaneous reactivity of these patients is
simultaneously demonstrated by a positive skin prick-test to either 9
% codeine phosphate or 10 mg/ml histamine. The IR unit of Stallergenes
is not comparable to the units used by other allergen manufacturers.
      </p>
      <p>
EDITORIAL NOTE: Should more manufacturer specific units come up in the 
future, we will include a manufacturer abbreviation in the unit symbol.
      </p>

comment:4 Changed 8 years ago by Gunther Schadow

Note: the [IR] unit symbol had been promised here for quite some time. It now is more clear that this is a manufacturer specific unit, and it should not have assigned such a generic symbol. In the future we would have done something like [IR'St] or some such to indicate this particularity.

comment:5 Changed 8 years ago by Gunther Schadow

Resolution: fixed
Status: assignedclosed

Done: [16412]

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